use strict;
my $str = '<div>
<iframe src="https://youtube.com"></iframe>
<iframe src="http://www.youtube.com"></iframe>
<iframe class="test" src="http://youtu.be/123"></iframe>
<iframe src="https://yoursite-is-safe-from-gdpr.com"></iframe>
</div>';
my $regex = qr/<iframe.+src="https?:\/\/(?:www.)?youtu\.?be(?:\.com)?.+<\/iframe>/mip;
my $subst = '<div>You must accept cookies before seeing this video content</div>';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html