$re = '/^(?!.*?(\S).*\1.*\1)(?:\b ?[a-f\d]{2}){16}$/m';
$str = 'Valid matches examples:
33 e0 f1 76 9c 4f a8 6c 01 5d 45 9e 28 db 7b 2a
Invalid matches examples:
c0 b0 f5 60 02 8b 1c a4 41 7c 53 f2 85 20 a0 d1
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php