#include <MsgBoxConstants.au3> ; to declare the Constants of MsgBox
Local $sRegex = "^([a-zA-Z0-9].+?)(\s+)((?:(?!0000)[0-9]{4}-(?:(?:0[1-9]|1[0-2])-(?:0[1-9]|1[0-9]|2[0-8])|(?:0[13-9]|1[0-2])-(?:29|30)|(?:0[13578]|1[02])-31)|(?:[0-9]{2}(?:0[48]|[2468][048]|[13579][26])|(?:0[48]|[2468][048]|[13579][26])00)-02-29))(\s+)((0?9|1[0-9]|2[01]):00~(1[0-9]|2[0-2]):00)(\s+)([A-D])(\sC)"
Local $sString = "U001 2020-01-01 9:00~22:00 A C"
Local $sSubst = ""
Local $sResult = StringRegExpReplace($sString, $sRegex, $sSubst)
MsgBox($MB_SYSTEMMODAL, "Result", $sResult)
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for AutoIt, please visit: https://www.autoitscript.com/autoit3/docs/functions/StringRegExp.htm