const regex = /(?:\b)(?!let)(?=\w+\sfirst_name\s+(know|keep|enjoy))(\w+ \w+)\s+(\w+)/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?:\\b)(?!let)(?=\\w+\\sfirst_name\\s+(know|keep|enjoy))(\\w+ \\w+)\\s+(\\w+)', 'g')
const str = `a reasons first_name keep waking up at night, is blah blah blah. Try this, let first_name know and see blah blah blah. Remember that first_name enjoy being challenged and blah blah blah`;
const subst = `\2 _object_s`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions