$re = '/(<iframe.+?src=".*?)(?=:)/';
$str = '<p>Some random text <iframe width="425" src="http://some-random-link.com" height="350" frameborder="0"></iframe></p>';
$subst = "\1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php