$re = '/\s*\b\d+\b\s*/m';
$str = '0 I64 EB MM 93
1519 KINGSCROSS RD
28 VA288 298
JOHN RANDOLPH RD
4700 WALMSLEY BL
BOWLING GREEN RD / BOB WHITE RD
BRUCE CT /FLORIDA AV
BUCK RD AND WHITEHALL RD
DOWNTOWN EWRESSWY EB 2ND ST
HYHLAND VISTA / GEORGE WASHINGTON BL
HYHLAND VISTA / GEORGE WASHINGTON BL
HYHLAND VISTA DR / GEORGE WASHINGTON BL
I95 25 43
LAUARL RIDGE MILL RD /CLARENCE RD
LAUARL RIDGE MILL RD /CLARENCE RD
NOVAH HOWARD ST /SEMINARY RD
OLD COUVAHOUSE RD R COUVAHOUSE RD
OLD COUVAHOUSE RD R COUVAHOUSE RD
WOODLAND AND ROANOKE
1501 SAMS CR1
15281 WHITEHEAD RD
1532 MARLBORO ST
16907 BRANDERS BRIDGE RD
1750 WILLIAM ST';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php