re = /\s*\b\d+\b\s*/m
str = '0 I64 EB MM 93
1519 KINGSCROSS RD
28 VA288 298
JOHN RANDOLPH RD
4700 WALMSLEY BL
BOWLING GREEN RD / BOB WHITE RD
BRUCE CT /FLORIDA AV
BUCK RD AND WHITEHALL RD
DOWNTOWN EWRESSWY EB 2ND ST
HYHLAND VISTA / GEORGE WASHINGTON BL
HYHLAND VISTA / GEORGE WASHINGTON BL
HYHLAND VISTA DR / GEORGE WASHINGTON BL
I95 25 43
LAUARL RIDGE MILL RD /CLARENCE RD
LAUARL RIDGE MILL RD /CLARENCE RD
NOVAH HOWARD ST /SEMINARY RD
OLD COUVAHOUSE RD R COUVAHOUSE RD
OLD COUVAHOUSE RD R COUVAHOUSE RD
WOODLAND AND ROANOKE
1501 SAMS CR1
15281 WHITEHEAD RD
1532 MARLBORO ST
16907 BRANDERS BRIDGE RD
1750 WILLIAM ST'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html