$re = '/^(?!\d{2}\h*[:-]\h*\d{2}\h*$).*[\r\n]+/m';
$str = '01 - 10
This is the first one :1
02:45
This is the second one -2
03-88
This is the third one "3
04:40
This is the forth one ;4
05 - 50
This is the fifth one .5';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php