$re = '/(^From\:\s|(?!^)\G).*?(\n\s+(.*?))*\K[^\x00-\x7F]/m';
$str = 'From: teéstéáű';
$subst = "_";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php