re = /(?:\G(?!\A)|^(?!.*\.join\.))(.*?)PD_/m
str = 'it.mycompany.db.beans.str1.PD_T_PD_CLASS
it.mycompany.db.beans.join.PD_T_CLASS
it.mycompany.db.beans.str2.PD_T_CLASS_1
it.mycompany.db.beans.join.PD_T_CLASS_1
PD_T_CLASS myVar = new PD_T_CLASS();
myVar.setPD_T_CLASS(something);'
subst = '$1'
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html