use strict;
my $str = 'Keep1
{/*DELETE}
Delete1a
{/*DELETE}
Delete2
{DELETE*/}
Delete1b
{DELETE*/}
Keep2
{/*DELETE}
Delete3
{DELETE*/}
Keep3';
my $regex = qr/^\s*\{\/\*DELETE}(\s*(?:\r?\n(?!\s*\{(?:\/\*DELETE|DELETE\*\/)}).*)*)\r?\n\s*\{DELETE\*\/}\s*$/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html