$re = '/(?<=[.?!]|^)(?:СЛОВО2()|СЛОВО()(?:\1())?|[^.?!])++\2(?!\3)/';
$str = 'Раз СЛОВО2 два СЛОВО.
Раз СЛОВО два СЛОВО2 три СЛОВО.
Раз СЛОВО два СЛОВО2.';
$subst = " ЗАМЕНА";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php