$re = '~(?:^.*?\.com/|(?<!^)\G)[^/\h]*\K/~m';
$str = '/foo/bar/baz/xyz
http://example.com/foo/12/jacket Input/Output /foo/bar/baz/xyz';
$subst = "|";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php