$re = '/src=([\'"])(https?:\/\/[^ >]*?youtu\.?be[^ >]+?)(?=\1)/';
$str = '<iframe width="425" height="349" src="http://www.youtube.com/embed/8tPnX7OPo0Q" frameborder="0" allowfullscreen></iframe>';
$subst = "src=\1\2?wmode=transparent";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php