re = /\n(?![^<]*<\/pre>)/m
str = '<p>Test contennt for regex
with line breaks</p>
<pre>code block
with multi line content
working fine</pre>
<pre class="brush:C#">
test line break before
open paranthesis < is not working fine
line breaks after paranthesis
is accepted
</pre>'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html