$re = '/[\r\n]?BEGIN((?!TRUE).)*?END/s';
$str = 'BEGIN
DESCRIPTION: 1234
BOOL:TRUE
END
BEGIN
DESCRIPTION: 4568
BOOL:TRUE
END
BEGIN
DESCRIPTION: 715310
BOOL:FALSE
END
BEGIN
DESCRIPTION: 12489453
BOOL:TRUE
END
BEGIN
DESCRIPTION: 41543
BOOL:FALSE
END';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php