$re = '~(http://images\.(\d+)_120\*75)(?![\s\S]*\1)~m';
$str = 'http://images.123456_120*75
http://images.123456_120*75
http://images.784217_120*75
http://images.784217_120*75
http://images.123456_120*75
http://images.123456_120*75
http://images.784217_120*75
http://images.784217_120*75
http://images.123456_120*75
http://images.123456_120*75
http://images.784217_120*75
http://images.784217_120*75';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php