use strict;
my $str = 'Joëlle;Dupont;123456;joëlle.dupont@mail.com
Alex;Léger;134234;alex.léger@mail.com';
my $regex = qr/[\xE8-\xEB](?!.*;)/p;
my $subst = 'e';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html