use strict;
my $str = '111 is different from:
111 is different from:
123 is different from:
567.';
my $regex = qr/(?m)^(\d{3}) .+:(\r?\n)(?!\1)(?=(\d{3})\b)/ip;
my $subst = '$0 This value $3 ***$2';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html