$re = '/ASP\.NET_SessionId=[a-z0-9]*[^a-z0-9;][^;]*;\s*/';
$str = 'PortalAlias=Portal; Language_PostPortal=en-US; ASP.NET_SessionId=opn4y4n1qja0mtzm4sx4514\'or+1=1--; portalroles=50FA411EBBAC79';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php