const regex = /<item (.*)(Misc\/)(\d*)_(\w*)_(\d*)(.*)(\w*) id="([^*])(\d*)(.+)_(\d+)(\w*)(.*")(.*=")(\w*)(.*)" \/>/gi;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('<item (.*)(Misc\\\/)(\\d*)_(\\w*)_(\\d*)(.*)(\\w*) id="([^*])(\\d*)(.+)_(\\d+)(\\w*)(.*")(.*=")(\\w*)(.*)" \\\/>', 'gi')
const str = `<item href="Misc/9781620025420_epub3_001.smil" id="x9781620025420_epub3_001.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_001.smil" id="x9781620025420_epub3_001.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_002.smil" id="x9781620025420_epub3_002.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_003.smil" id="x9781620025420_epub3_003.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_004.smil" id="x9781620025420_epub3_004.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_005.smil" id="x9781620025420_epub3_005.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_006.smil" id="x9781620025420_epub3_006.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_007.smil" id="x9781620025420_epub3_007.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_008.smil" id="x9781620025420_epub3_008.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_009.smil" id="x9781620025420_epub3_009.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_010.smil" id="x9781620025420_epub3_010.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_011.smil" id="x9781620025420_epub3_011.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_012.smil" id="x9781620025420_epub3_012.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_013.smil" id="x9781620025420_epub3_013.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_014.smil" id="x9781620025420_epub3_014.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_015.smil" id="x9781620025420_epub3_015.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_016.smil" id="x9781620025420_epub3_016.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_017.smil" id="x9781620025420_epub3_017.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_018.smil" id="x9781620025420_epub3_018.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_019.smil" id="x9781620025420_epub3_019.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_020.smil" id="x9781620025420_epub3_020.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_021.smil" id="x9781620025420_epub3_021.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_022.smil" id="x9781620025420_epub3_022.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_023.smil" id="x9781620025420_epub3_023.smil" media-type="text/plain" />
<item href="Misc/9781620025420_epub3_024.smil" id="x9781620025420_epub3_024.smil" media-type="text/plain" />`;
const subst = `<item \1\2\3\4_\5.\6 id="\7\8\9_\10\11\12\13\14\15\16\17`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions