use strict;
my $str = 'site.org asp.net dsgsvgs somedomain.com sdbbdsb vb.net otherdomain.org vs.net wax.museum somesite.net vb.net micro.co.uk sdbsdbssd asp.co.uk visualbasic.co.hk ASP.net visualstudio.co.jp ddddddd visualbasic.net visual basic.net visual studio.net uuu. www.com';
my $regex = qr/(^|\s)(?!\b(?:basic|studio|asp|v[bs]|c\#)\.net)(\w+)(?:\.co\.[a-z]{2}|\.[a-z]{2,6})\b/ip;
my $subst = '\\1\\2';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html