re = /(?<=([aui]))[wy](?=\1)|(?<=i)[wy](?=u)/
str = 'asdawasda
asdayasda
asdiwisda
asdiyisda
asduwusda
asduyusda
asdawisda
asdawusda
asdayisda
asdayusda
asdiwasda
asdiwusda
asdiyasda
asdiyusda
asduwasda
asduwisda
asduyasda
asduyisda
ramiyun
da9iwun'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html