# If you'd like to omit non-matching lines from the result; add ';d' to the end of the expression.
sed -E 's/\b(?:food(?: (?:microbiology|safety))?|microbiology and food)\b/<span title="" data-term="T: $&" class="grams">$&<\/span>/gmi;t' <<< "Welcome to MOOC on Food Microbiology and Food Safety. I am Dr. xyz, Coordinator of this course, which is designed under the guidance of Prof. pqrs."
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for SED, please visit: https://www.gnu.org/software/sed/manual/html_node/The-_0022s_0022-Command.html