use strict;
my $str = 'OPTIONS="-x -u wrong:wrong -c blah"
OPTIONS="-u wrong:wrong -x -c blah"
OPTIONS="-x -c blah -u wrong:wrong"
OPTIONS="-x -c blah"';
my $regex = qr/OPTIONS=\"(?:(.*)(-u [a-z]+:[a-z]+))?(.*?)\"/mp;
my $subst = 'OPTIONS="\\1 \\3 -u ntpd:ntpd"';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html