$re = '/.*<!\[CDATA\[de_DE\]\]>.*(?:\r?\n)?/m';
$str = '<supported-languages>
<lang><![CDATA[en_US]]></lang>
<lang><![CDATA[es_ES]]></lang>
<lang><![CDATA[de_DE]]></lang>
</supported-languages>
<2ndsupported-languages>
<lang><![CDATA[en_US]]></lang>
<lang><![CDATA[es_ES]]></lang>
<lang><![CDATA[de_DE]]></lang>
</2ndsupported-languages>';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php