$re = '/(.*),(.*),(.*),(.*),(.*),(.*)/m';
$str = 'Address,Name,Lat,Long,2016 Sales,Type
48 Park Avenue, LATTON, SN6 4SZ,Nikki Yellowbeard,-23.17549,36.74641,9727,AA
IV21 1TD 116 Walwyn Rd CHARLESTOWN,Jonh Doe,-10.98309,156.41854,11932,AE';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php