const regex = /data:.+;base64,(.*)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('data:.+;base64,(.*)', 'gm')
const str = `data:image/jpeg;base64,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`;
const subst = `$1`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions