const regex = new RegExp('\\b(https?://\\S+/)[^\\s?#/]+(?![^\\s?#])', 'gm')
const str = `For any of the following URLs, I'm looking for a match for segment as follows:
https://example.com/what-not/segment matches segment
https://example.com/what-not/segment?a=b matches segment
https://example.com/what-not/segment#a matches segment
In case there is a match for segment, I'm going to replace it with segment/.
For any of the following URLs, there should be no match:
https://example.com/what-not/segment/ no match
https://example.com/what-not/segment/?a=b no match
https://example.com/what-not/segment/#a no match
`;
const subst = `$1segment/`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions