$re = '/^(((A[BL]|B[ABDFHLNRSTX]?|C[ABFHMORTVW]|D[ADEGHLNTY]|E[CHNX]?|F[KY]|G[LUY]?|H[ADGPRSUX]|I[GMPV]|JE|K[ATWY]|L[ADELNSU]?|M[EKL]?|N[EGNPRW]?|O[LX]|P[AEHLOR]|R[GHM]|S[AEGKLMNOPRSTWY]?|T[ADFNQRSW]|UB|W[ACDFNRSV]?|YO|ZE)(\d[\dA-Z]?) ?(\d)([A-Z]{2})$)|((A[BL]|B[ABDFHLNRSTX]?|C[ABFHMORTVW]|D[ADEGHLNTY]|E[CHNX]?|F[KY]|G[LUY]?|H[ADGPRSUX]|I[GMPV]|JE|K[ATWY]|L[ADELNSU]?|M[EKL]?|N[EGNPRW]?|O[LX]|P[AEHLOR]|R[GHM]|S[AEGKLMNOPRSTWY]?|T[ADFNQRSW]|UB|W[ACDFNRSV]?|YO|ZE)(\d[\dA-Z]?) ?(\d))$)/mi';
$str = 'S4 1XL
B40 9PL
GU1 1SB
NG17 7TS
SW1A3BX
po1 1';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php