$re = '/\s*([0-9]*)\s((NW|SW|SE|NE|S|N|E|W))?(.*)((NW|SW|SE|NE|S|N|E|W))?((#|APT|BSMT|BLDG|DEPT|FL|FRNT|HNGR|KEY|LBBY|LOT|LOWR|OFC|PH|PIER|REAR|RM|SIDE|SLIP|SPC|STOP|STE|TRLR|UNIT|UPPR|\,)[^,]*)(\,)([\s\w]*)\n/i';
$str = '5141 NW OAKLAND PARK BOULEVARD NW #109, LAUDERDALE LAKES
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php