const regex = /(.*Itemid=)(?!527)(\d*)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(.*Itemid=)(?!527)(\\d*)', 'gm')
const str = `/docman/?view=document&alias=690-uchwala-rady-miasta-nr-xv-100-2015-zmieniajaca-uchwale-nr-xxxiii-151-2012&category_slug=gminne-programy-i-strategie&Itemid=123
/docman/?view=document&alias=690-uchwala-rady-miasta-nr-xv-100-2015-zmieniajaca-uchwale-nr-xxxiii-151-2012&category_slug=gminne-programy-i-strategie&Itemid=494
/docman/?view=document&alias=690-uchwala-rady-miasta-nr-xv-100-2015-zmieniajaca-uchwale-nr-xxxiii-151-2012&category_slug=gminne-programy-i-strategie&Itemid=527`;
const subst = `${1}494`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions