const regex = /^\s*#.*$/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('^\\s*#.*$', 'gm')
const str = `#Processed by Id: cwm.py,v 1.197 2007/12/13 15:38:39 syosi Exp
# using base http://www.prodigi.eu/instances
# Notation3 generation by
# notation3.py,v 1.200 2007/12/11 21:18:08 syosi Exp
# Base was: http://www.prodigi.eu/instances
@prefix : </ac-schema#> .
@prefix ins: </instances#> .
@prefix olanet: <http://www.ibermaticaindustria.com/soluciones/planta-mes-olanet#> .
@prefix plm: <http://hms.ifw.uni-hannover.de/#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
ins:everyone a <http://xmlns.com/foaf/0.1/Group>;
:canSee ins:public;
rdfs:member <http://127.0.0.1/OslcOlanetProvider/api/producer/01>,
#abul maal abdul muhit
[...]`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions