$re = '/\b(?:in|and|is)\s+((?:.(?!\b(?:in|and|is)\b))*(?:HomeStay|Luxury)(?:.(?!\b(?:in|and|is)\b))*)(?!.*(?:HomeStay|Luxury).*)/m';
$str = 'Hello, tonight I\'m in the town of Trenton in Hotel HomeStay [123] in New Jersey and I will be staying in Hotel HomeStay [123] and I have no money. Actually, I\'m wealthier than this guy outside, I will be staying in Hotel HomeStay [123] and I have tons of money. in Hotelin HomeStay [123in]. HomeStay and never gonna give you up, never gonna make you cry. This is Luxury, and a cheeseburger.
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php