use strict;
my $str = '<165>
User.Notice 2016-01-02 00:00:33 1.1.66.15 1.1.66.15 02/01/2016 00:00:00 NTP: Synchronization OK.
Local7.Warning 2016-01-02 00:00:43 1.1.5.6 319129: 14w1d: %CDP-4-NATIVE_VLAN_MISMATCH: Native VLAN mismatch discovered on GigabitEthernet1/0/21 (780), with name_a FastEthernet3 (1).
';
my $regex = qr/((?<syslog_pri>(^\<\d*\>))|(^(?<facility>[^\.]*)\.(?<severity>[^\s]*)))?\s*(?:%{SYSLOGTIMESTAMP:timestamp}|%{TIMESTAMP_ISO8601:timestamp}) %{SYSLOGHOST:iporhost}(?<messgae>.*)/p;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html