$re = '/[^.]+_([^.]+\.[^.]+)/m';
$str = '"1234_4534_41247612_2462184_2131_ABCDEF.GHI.xlsx"
"1234_4534__sfhaksj_DHJKhd_hJD_41247612_2462184_2131_PQRST.GHI.xlsx"
"12JSAF34_45aAF34__sfhaksj_DHJKhd_hJD_41247612_2f462184_2131_JKLMN.OPQ.xlsx"
"1234_4534__sfhaksj_DHJKhd_hJD_41FA247612_2462184_2131_WXY.TUV.xlsx"';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php