$re = '/__[A-Z0-9_]+__\(\s*(?:\'[^\']*\'|\d+)(?:\s*,\s*(?:\'[^\']*\'|\d+))*\s*\)/m';
$str = '5 + __FXN1__(\'hello\', 1, 3, \'__HELLO__(hello) + 5\') + 5 + (2/2) + __FXN2__(\'Good boy\')';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php