use strict;
my $str = '<?xml version="1.0" encoding="UTF-8"?>
<root xmlns:xx12="www.example.com">
<xx12:matchNode so="what">also matched</xx12:matchNode>
<matchNode/>
<matchNode>matched</matchNode>
<xx12:matchNode/>
<unmatchNode>
</unmatchNode>
<xx12:matchNode>also matched</xx12:matchNode>
<matchNode attr="12" test="false">
matched
</matchNode>
</root>';
my $regex = qr/((<([a-zA-Z0-9]*:)*matchNode[^>]*)\/\s*>)|(((<([a-zA-Z0-9]*:)*matchNode[\s\S]*?)>(([\s\S]*?)))<\/([a-zA-Z0-9]*:)*matchNode>)/p;
my $subst = '$2$6>(obfuscated...)</$3$7matchNode>';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html