const regex = /(?:\uD81A[\uDF40-\uDF43]|\uD81B[\uDF93-\uDF9F\uDFE0]|[\u006E\u00B0\u00B2\u00B3\u00B9\u02AF\u0670\u0711\u2121\u213B\u2207\u29B5\uFC5B-\uFC5D\uFC63\uFC90\uFCD9\u2070\u2071\u2074-\u208E\u2090-\u209C\u0345\u0656\u17D2\u1D62-\u1D6A\u2A27\u2C7C\u02B0-\u02C1\u02C6-\u02D1\u02E0-\u02E4\u02EC\u02EE\u0374\u037A\u0559\u0640\u06E5\u06E6\u07F4\u07F5\u07FA\u081A\u0824\u0828\u0971\u0E46\u0EC6\u10FC\u17D7\u1843\u1AA7\u1C78-\u1C7D\u1D2C-\u1D6A\u1D78\u1D9B-\u1DBF\u2071\u207F\u2090-\u209C\u2C7C\u2C7D\u2D6F\u2E2F\u3005\u3031-\u3035\u303B\u309D\u309E\u30FC-\u30FE\uA015\uA4F8-\uA4FD\uA60C\uA67F\uA69C\uA69D\uA717-\uA71F\uA770\uA788\uA7F8\uA7F9\uA9CF\uA9E6\uAA70\uAADD\uAAF3\uAAF4\uAB5C-\uAB5F\uFF70\uFF9E\uFF9F])+/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(?:\\uD81A[\\uDF40-\\uDF43]|\\uD81B[\\uDF93-\\uDF9F\\uDFE0]|[\\u006E\\u00B0\\u00B2\\u00B3\\u00B9\\u02AF\\u0670\\u0711\\u2121\\u213B\\u2207\\u29B5\\uFC5B-\\uFC5D\\uFC63\\uFC90\\uFCD9\\u2070\\u2071\\u2074-\\u208E\\u2090-\\u209C\\u0345\\u0656\\u17D2\\u1D62-\\u1D6A\\u2A27\\u2C7C\\u02B0-\\u02C1\\u02C6-\\u02D1\\u02E0-\\u02E4\\u02EC\\u02EE\\u0374\\u037A\\u0559\\u0640\\u06E5\\u06E6\\u07F4\\u07F5\\u07FA\\u081A\\u0824\\u0828\\u0971\\u0E46\\u0EC6\\u10FC\\u17D7\\u1843\\u1AA7\\u1C78-\\u1C7D\\u1D2C-\\u1D6A\\u1D78\\u1D9B-\\u1DBF\\u2071\\u207F\\u2090-\\u209C\\u2C7C\\u2C7D\\u2D6F\\u2E2F\\u3005\\u3031-\\u3035\\u303B\\u309D\\u309E\\u30FC-\\u30FE\\uA015\\uA4F8-\\uA4FD\\uA60C\\uA67F\\uA69C\\uA69D\\uA717-\\uA71F\\uA770\\uA788\\uA7F8\\uA7F9\\uA9CF\\uA9E6\\uAA70\\uAADD\\uAAF3\\uAAF4\\uAB5C-\\uAB5F\\uFF70\\uFF9E\\uFF9F])+', 'g')
const str = `ᵀᴹ ¹²³ ⁰⁴Txtͅ ٖ ្ ᵢ ᵣ ᵤ ᵥ ᵦ ᵧ ᵨ ᵩ ᵪ ₀ ₁ ₂ ₃ ₄ ₅ ₆ ₇ ₈ ₉ ₊ ₋ ₌ ₍ ₎ ₐ ₑ ₒ ₓ ₔ ₕ ₖ ₗ ₘ ₙ ₚ ₛ ₜ ⨧ ⱼ n ° ² ³ ¹ ʯ ٰ ܑ ⁰ ⁱ ⁴ ⁵ ⁶ ⁷ ⁸ ⁹ ⁺ ⁻ ⁼ ⁽ ⁾ ⁿ ℡ ℻ ∇ ⦵ ﱛ ﱜ ﱝ ﱣ ﲐ ﳙ `;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions