$re = '~^.*\R.*/movie/.*\R~m';
$str = '#EXTINF:-1,Wreck-It Ralph
http://p5.giffy.be:8080/movie/RghyHCIE4i/SDrQatrZkx/104880.mp4
#EXTINF:-1,Wrinkle-Free
http://p5.giffy.be:8080/movie/RghyHCIE4i/SDrQatrZkx/105060.mp4
#EXTINF:-1,DR | TELEMICRO 5
http://p5.giffy.be:8080/RghyHCIE4i/SDrQatrZkx/99633
#EXTINF:-1,Wrong Mistake - Short Movie
http://p5.giffy.be:8080/movie/RghyHCIE4i/SDrQatrZkx/106840.mp4
#EXTINF:-1,DR | TELESISTEMA 11
http://p5.giffy.be:8080/RghyHCIE4i/SDrQatrZkx/99632
#EXTINF:-1,Wreck-It
http://p5.giffy.be:8080/movie/RghyHCIE4i/SDrQatrZkx/104707.mp4
#EXTINF:-1,DR | TELEUNIVERSO
http://p5.giffy.be:8080/RghyHCIE4i/SDrQatrZkx/99631';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php