re = /^(?:(?:[!#].*)?\n)+/
str = '
# catch this comment
!mycommand
# catch this comment
#catch this comment too
!mycommand
# catch this comment
!mycommand
!mycommand
some code. match until the previous line
# do not catch this comment
!mycommand
# do not catch this comment'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html