const regex = /(youtu.*be.*)\/(watch\?v=|embed\/|v|shorts|)(.*?((?=[&#?])))/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(youtu.*be.*)\\\/(watch\\?v=|embed\\\/|v|shorts|)(.*?((?=[&#?])))', 'gm')
const str = `<p>http://www.youtube.com/watch?v=0zM3nApSvMg&feature=feedrec_grec_index <br><br>https://youtube.com/shorts/0dPkkQeRwTI</p><h2>Para</h2>
<p>http://www.youtube.com/user/IngridMichaelsonVEVO#p/a/u/1/QdK8U-VIH_o</p><p>Para</p>
<p>http://www.youtube.com/v/0zM3nApSvMg?fs=1&hl=en_US&rel=0</p><p>Para</p>
<p><br>http://www.youtube.com/watch?v=0zM3nApSvMg#t=0m10s</p><p>Para</p>
<p>Check out my youtube video: http://www.youtube.com/embed/0zM3nApSvMg?rel=0</p><p>Para</p>
<p>http://www.youtube.com/watch?v=0zM3nApSvMg</p><p>Para</p>
<p><br>http://youtu.be/0zM3nApSvMg</p><p>Para</p>
<div>https://youtube.com/shorts/0dPkkQeRwTI?feature=share</div>
<p>https://youtube.com/shorts/0dPkkQeRwTI</p><p>Para</p>
<p>https://www.youtube.com/watch?v=0dPkkQeRwTI&ab_channel=RelaxedChan</p><p>Para</p>`;
const subst = `<iframe width="100%" src="https://www.youtube.com/embed/$3" frameborder="0" allowfullscreen></iframe>`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions