$re = '/\b(NUMBER|[XYZAB])\:=([^,]+),/';
$str = 'DRILL(NUMBER:=20,NAME:=\'4\',PN:=1,X:=10.1,Y:=73.344,Z:=0,A:=-1.435,B:=1.045,M1:=1,M2:=2,M3:=3,M4:=4,M5:=1,S1:=10.5,S2:=2.1,S3:=1.2,S4:=2,S5:=2.4,RS1:=1,RS2:=2);
NUMBER, X, Y, Z, A, B
';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php