$re = '/\b((?:[Ee]tc|St|Gen|Hon|Prof|Dr|Mr|Ms|Mrs|[JS]r|Col|Maj|Brig|Sgt|Capt|Cmnd|Sen|Rev|Rep|Revd|pp|[Vv]iz|i\.?\s*e|[Vvol]|[Rr]col|maj|Lt|[Ff]ig|[Ff]igs|[Vv]iz|[Vv]ols|[Aa]pprox|[Ii]ncl|Pres|[Dd]ept|min|max|[Gg]ovt|lb|ft|c\.?\s*f|vs|\p{Lu}(?:\.\p{Lu})+)\.)|[^0-9\p{L}]/u';
$str = 'F.B.I.Federal.Bureau.of.Investigation.Dr.Mannon';
$subst = "$1 ";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php