use strict;
my $str = 'U001 2020-01-01 9:00~22:00 A C';
my $regex = qr/^([a-zA-Z0-9].+?)(\s+)((?:(?!0000)[0-9]{4}-(?:(?:0[1-9]|1[0-2])-(?:0[1-9]|1[0-9]|2[0-8])|(?:0[13-9]|1[0-2])-(?:29|30)|(?:0[13578]|1[02])-31)|(?:[0-9]{2}(?:0[48]|[2468][048]|[13579][26])|(?:0[48]|[2468][048]|[13579][26])00)-02-29))(\s+)((0?9|1[0-9]|2[01]):00~(1[0-9]|2[0-2]):00)(\s+)([A-D])(\sC)/p;
my $subst = '';
my $result = $str =~ s/$regex/$subst/r;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html