const regex = /((\||(?<!^)\G)[^,|]*),(?=.*\|)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('((\\||(?<!^)\\G)[^,|]*),(?=.*\\|)', 'gm')
const str = `div-item-2,4,maintype:social| heading:sdfsdf| social: 1, 2, 3 | table:Social| item:3| align:vertical| style:icon| isactive:1,8,0
div-item-0,4,maintype:menu| heading:Quick, Link| table:Menu | menuid:1| align:vertical| style:icon| isactive:1,0,0
div-item-1,4,maintype:text| heading: Name | title: Learn from here| logo:/photos/20/01.jpg| description: This is some description, so you can stay with us| isactive:1,4,0`;
const subst = `$1;`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions