const regex = /(((?:[+\-\/*]6+|6+[+\-\/*]|([^6]|\b)6{1,2}(?3)|(?3)6{6,}(?3)|[0-57-9]6+|6+[0-57-9])(*SKIP)(*F))|6)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(((?:[+\\-\\\/*]6+|6+[+\\-\\\/*]|([^6]|\\b)6{1,2}(?3)|(?3)6{6,}(?3)|[0-57-9]6+|6+[0-57-9])(*SKIP)(*F))|6)', 'gm')
const str = `66
老铁666这类的, 6666
三到五个六66666
5666有其他数字不替换
6665
566665
666666
66
+66
666-
`;
const subst = `六`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions