const regex = /(\(\d+), '(.*?)(?:[|]{3}.*?)?', (\d+\),?)/gm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('(\\(\\d+), \'(.*?)(?:[|]{3}.*?)?\', (\\d+\\),?)', 'gm')
const str = `(37, '2011-01/1295144032_x_7cb0bcf1.jpg|||2011-01/1295266037_small_carterthal1.jpg.jpg|||2014-05/1401429739_3-fundamenta-vidyatshih2.jpg', 66),
(38, '2011-01/1295266433_event-image-poster.jpg|||2011-01/1295279508_16f7cb40.jpg', 67),
(39, '2012-01/1295277340_1.jpg|||2011-01/1295278172_08a9e04f4264-300x298.jpg|||2014-05/1401428634_vladislav-erko-castaneda-9.jpg', 68),
(68, '2011-03/1300177205_usui.jpg', 393),
(37, 'upload/2011-01/1295144032_x_7cb0bcf1.jpg', 66),
(38, 'upload/2011-01/1295266433_event-image-poster.jpg', 67),
(39, 'upload/2012-01/1295277340_1.jpg', 68),`;
const subst = `$1, 'upload/$2', $3`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions