$re = '~(?:<p>(?=[^<>]*</p>)|\G(?!^))[^\d<>]*\d+\K\h~m';
$str = '<p>My 90 days 123 work.</p>';
$subst = " ";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php