#include <MsgBoxConstants.au3> ; to declare the Constants of MsgBox
Local $sRegex = "(?m)(?<=^|[^_])__((?![\s_])(([^_]|_(?!_))+?)?[^\s_])__(?=[^_]|$)"
Local $sString = "-- funciona" & @CRLF & _
                "__foo bar__" & @CRLF & _
                "__f o o b a r__" & @CRLF & _
                "**teste __lorem ipsum__ dolor sit**" & @CRLF & _
                "__teste **lorem ipsum** dolor sit__" & @CRLF & _
                "abc__xyz__teste" & @CRLF & _
                "" & @CRLF & _
                "-- não funcionava na primeira versão" & @CRLF & _
                "__foo_bar__" & @CRLF & _
                "__a__" & @CRLF & _
                "__*__" & @CRLF & _
                "__foo_*bar__" & @CRLF & _
                "" & @CRLF & _
                "-- não é para funcionar" & @CRLF & _
                "__ foo bar__" & @CRLF & _
                "__foo bar __" & @CRLF & _
                "_foo__" & @CRLF & _
                "__ foo __" & @CRLF & _
                "_foo_" & @CRLF & _
                "__foo_" & @CRLF & _
                "__ __" & @CRLF & _
                "__a____" & @CRLF & _
                "____a__" & @CRLF & _
                "_____" & @CRLF & _
                "" & @CRLF & _
                "-- corner case: aninhado (não tratei pois não sei o que deveria fazer)" & @CRLF & _
                "__abc__xyz__123__" & @CRLF & _
                "__abc __xyz__ 123__" & @CRLF & _
                ""
Local $sSubst = "<i>\1<\i>"
Local $sResult = StringRegExpReplace($sString, $sRegex, $sSubst)
MsgBox($MB_SYSTEMMODAL, "Result", $sResult)
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for AutoIt, please visit: https://www.autoitscript.com/autoit3/docs/functions/StringRegExp.htm